Francesco di Paola Villadecani (born 22 February 1780 in Messina in Sicily in Italy, died 13 June 1861 in Messina) was a cardinal of the Catholic Church and was Archbishop of Messina from 1823 to 1861.
He was made a cardinal in January 1843 by Pope Gregory XVI.
He did not take part in the 1846 conclave which chose Pope Pius IX.